Entries from 2023-04-01 to 1 month

Wnt7b is sublayer and deeplayer ligand appear during late second trimester

The WNT/β-catenin pathway genes, including WNT7B, are specifically enriched in the deep layers and subplate in the human embryonic cortex during the late second trimester (Abu-Khalil et al., 2004; Miller et al., 2014). WNT/β-catenin signal…

Wnt signal expand mensenchyme cells and induce invagination of the dorsal telencephalon

Constitutively active floxed version of ß-catenin [Ctnnb1(gof)] and crossed these with Sox10-Cre (nerual crest cell specific marker) mice. Col2a1, a marker of condensing calvarial mesenchymal cells [23], [33], revealed that Col2a1+ mesench…

Neural crest and mensenchyme in telencephalon invaginates

Cranial neural crest cells to mesenchymal progenitors forming the mesenchymal derivatives of head and face Neural crest cells detach from neural tube one day before dorsalmedial organoizer formation (also the invagination) A unique feature…

Hippocampus development from medial pallium

Hippocampus is divided into distinct regions in vivo: CA1 and CA3 of Ammon’s horn, and the dentate gyrus (DG) . CA fields and DG consist of neurons with large pyramidal somata and small granule somata, respectively. Besides the cell morpho…