2002, Science, Overexpression of β-catenin expand mouse cerebral cortex dramatically. Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors Animals were exposed to a single-pulse label of BrdU 24 hours bef…

Phospho-Histone H3 (Ser10) The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications ( methyl or acetyl groups to lysine and arginine amino acids and t…

Four considerations for the perfect recombinant AAV (rAAV) tool AAV can used in a wide variety of applications including transient gene expression in a particular cell type, CRISPR genome editing, optogenetics, and chemogenetics experiment…

Lentiviruses and AAV are the best, since they can both infect dividing and non-dividing cells. Lentivirus carry longer gene but cause insertional mutation at random sites, whereas AAV are safer (stay as episomal, do not integrate into host…

Science and Nature each one in 2019. Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex Early satge the cells are more introverted. Mainly based on intrinsc properties, such as cell cycle and c…

Here, we characterise a population of E11.5 RGCs that cannot be preferentially linked to deep- or upper-layer neurogenesis (The green cells) by our bioinformatic analysis. Consistent with this, these progenitors generated similar numbers o…

It is well understood that cell-cycle progression regulates many cellular processes beyond those required for cell division. For instance, CYCLIN-D1 has been previously described to induce an IPC state in the cortex17,18 and promote neurog…

We define organoids as in vitro-generated cellular systems that emerge by self-organization, include multiple cell types, and exhibit some cytoarchitectural and functional features reminiscent of an organ or organ region. Organoids can be …