Science and Nature each one in 2019.
Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex
Early satge the cells are more introverted. Mainly based on intrinsc properties, such as cell cycle and chromatin organization. As temporal progression, progenitors become more and more extraverted, receving environmental clues from outside, such as via membrane receptors and membrane potential control.
In another word, early progenitors are more multipotent, gradually lost their competence and be committed into certain neural lineage.
PRC2. regulating chromatin compactation, become one of the promising intrinsic factor regulating early progenitor multipotence. Loss of PRC2 premature cell lineage and induce UL neurons on early stage.
However. PRC2 is not cell autonomous factor by MADM single cell method.
https://www.science.org/doi/10.1126/science.aav2522
Here we specifically isolated apical progenitors and intermediate progenitors, and fate-mapped their respective neuronal progeny following heterochronic transplantation into younger embryos. We find that apical progenitors are temporally plastic and can re-enter past molecular, electrophysiological and neurogenic states when exposed to an earlier-stage environment by sensing dynamic changes in extracellular Wnt. By contrast, intermediate progenitors are committed progenitors that lack such retrograde fate plasticity. These findings identify a diversity in the temporal plasticity of neocortical progenitors, revealing that some subtypes of cells can be untethered from their normal temporal progression to re-enter past developmental states.
